There are quite a few popular launchers for your Android phone to breathe a bit of freshness into it, they all have different features it’s all about finding the best one that suites you! All of these can be downloaded from the Android Market and some also have the .apk available for those who don’t have a Market enabled Android device. The list below is a few that I have picked out that I personally think are worth checking out, so lets get started!
Launcher Pro
I’m currently using Launcher Pro myself and absolutely love messing around with all the features such as the 3D Drawer, Home Screen transition animations, define how many home screens/docks you want, which is a great option to include is it means you can make some really minimalistic interfaces just like mine:

Currently using the “wp clock light” live wallpaper on a single home screen and a single dock with just one button to open the applications menu. I have made it so that Launcher Pro can hide the status bar at the top but can reveal it by pressing the home button on my HTC Desire. Launcher Pro is free but you can pay for Launcher Pro Plus which will come with even more features and special widgets!
Download Launcher Pro from Market: https://market.android.com/details?id=com.fede.launcher
OR
Download the APK: http://www.launcherpro.com/
Zeam Launcher
Zeam launcher is designed to be lightweight on your Devices resources, this is great for the more cheaper, lower spec phones since it should make browsing through the phone a bit more snappier! Customizing the launcher is slightly more fiddly than say Launcher Pro (Trying to customize the dock, for example) but defiantly a must-have launcher if you want one that is light on your device’s hardware.

Download Zeam Launcher from Market: https://market.android.com/details?id=org.zeam
ADW.Launcher
ADW.Launcher is very similar to Launcher Pro, although it does feature a few different compared to Launcher Pro, such as Horizontal scrolling in the Applications menu which is great for Tablets since it means you don’t have to keep sliding your finger all the way across the display. 
The Launcher has got a fairly big community behind it which release all sorts of themes for the launcher since ADW.Launcher has theme support.
Download ADW.Launcher from the Market: https://market.android.com/details?id=org.adw.launcher
Go Launcher EX
Go Launcher EX is another launcher that is worth checking out, the reason why I like this launcher so much is it’s built in “Task Killer” so it means you don’t have to download any additional task killers. You can access the built in Task Killer by opening up the applications menu and clicking the third button on the top of the menu.

Download Go Launcher EX from the Market: https://market.android.com/details?id=com.gau.go.launcherex
OR
Download the APK: http://www.goforandroid.com/
Slidescreen
Slidescreen has got a very different interface compared to all the other Launchers, the layout means that you can access your Facebook stream, Twitter Feed, Missed calls, messages, emails and much more all from one home screen!

On the top half of the launcher you can quickly view any Missed calls, Messages, Emails and the Calendar. If don’t have any new missed calls, but have a lot of emails it can hide the missed calls tab to save space. On the Bottom half of the launcher you can have the following services: Google Reader, Stocks, Twitter and Facebook. Any of these services which are on the Top and Bottom of Slidescreen can be turned off if you don’t use them in the Settings menu, just press the menu button (Home Settings > Services).
There is a free version but it has advertisements on the bottom of the interface, though the full version is quite pricey since it’s $6.99 USD (around £4.23) for no other features other than there is no advertisements.
Download Slidescreen from Market: https://market.android.com/details?id=com.larvalabs.slidescreen
So there are 5 of the most popular Android Launchers to try out for yourself, if you have another suggestion of an Android Launcher that you enjoy using and think others should give it a try, suggest it in the comment box below!